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Archival description
James Alexander Little fonds Subseries
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APO C-II deficiency research

Series contains material documenting specific studies and general research within the Studies of Familial Apolipoprotein CII Deficiency project. Initiated in 1977, the project aimed to study family members with apolipoprotein C-II deficiencies in order to establish the clinical and genetic characteristics of the condition. Lead investigators were Diane Wilson Cox, Carl Breckenridge, and Alick Little. The project also included collaborative studies with external researchers. Included in the material are records related to the APO CII Deficient Pedigree Study and the Apoloprotein CII deficiency: An investigation of abnormalities of Lipids and Lipoproteins and the Anemia of Homozygotes project as well as documentation of field trips to the United States (Texas. Records include proposals, correspondence with patients, fellow researchers and doctors, patient records, data print-outs, family study questionnaires, lab results, and reports.

Coronary Primary Prevention Trial (CPPT) and other studies

Series consists of five files related to the Coronary Primary Prevention Trial (CPPT). The trial tested whether lowering plasma cholesterol would prevent fatal and non-fatal heart attacks. The clinical trial was conducted at the Toronto McMaster Lipid Research Centre as well as eleven other US centres. Series also includes a proposal for a second analysis for nutrient intake. Records include notes, summaries of results, speaking notes from a 1984 press conference, and commentary of published CPPT findings and data tape documentation.

Population (Prevalence) Studies

Series contains records documenting research performed as part of the Toronto McMaster Lipid Research Clinics Population (Prevalence) Studies. Comprised of a number of individual studies, the project analyzed data from more than 8,200 subjects from both Hamilton and Toronto over two visits. Material within the series includes progress reports from the initial visits in addition to representing specific component studies. Component studies included in the sub-series are morbidity and mortality follow-up studies, high-density lipoproteins triglyceride (HDL-TG) risk factor analysis, and the Toronto Hamilton Comparison Study. Records includes data, notes, correspondence, typescripts and tables.

Annual reports, articles, correspondence

This subseries consists of annual reports on the Atherosclerosis study from 1953 to 1962, correspondence with Sunnybrook Hospital and U of T. officials as well as colleagues relating to the project’s operations and manuscripts and off prints of articles describing the results of various studies.

Summarized data

This series contains summarized data for each subject patient (coronary and control), arranged by decade. Includes name of patient, study number, data relating to physical condition at various dates, occupation, social class, etc.

Control and coronary patient case files

This series contains patient case files for male veterans in two groups: the study group of patients with evidence of coronary heart disease and the control group of ‘normal’ patients with no evidence of coronary heart disease. Patients ranged in age from 30 years to approximately 80 years of age and were studied over a period of 10 years. The original folders along with the contents have been retained since important information was noted on the front of the folders by the project team. Case files are in numerical order reflecting the two groups and subdivided by decade (or age of patient, i.e. 4th decade = 30 to 39 years of age, 5th decade = 40-49 years of age, etc.) Case files contain correspondence, autopsy reports, data and test results, vital personal information.

Other studies

This subseries contains files relating to other studies conducted using data from this project. Between 1953 and 1956, Dr. Little and his team attempted to relate diet and the consumption of animal and vegetable fat. Files include some of the work of Dr. Fraser Mustard on butter and margarine. Other files relating to diet document the effect of coffee on serum lipids in the mid 1960’s. Dr. Little and Dr. Shanoff also studied the relationship of heart size to survival of males between the ages of 30 and 69 with myocardial infarction. They found that heart enlargement significantly reduced survival rates. Other files document diseases such as cirrhosis of the liver, diabetes mellitus, familial hypercholesterolemia, gout, hypertension, hypothyroidism, and obesity. Also included are studies of postmen (1954) and another on rugby players showing how exercise is associated with a high intake of calories without raising serum lipids.

Files may contain patient case information, correspondence, data and test results, and manuscripts of some articles and presentations.