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Donald was born 27 September, 1888 and graduated from the University of Toronto with a BA in 1912 and an MB in 1915. Following active service in World War I, he joined the University's Antitoxin Laboratory (later the Connaught Laboratories), where he was eventually appointed Assistant Director. In 1920 he was appointed to the staff of the Department of Hygiene and Preventive Medicine in the Faculty of Medicine and helped develop the School of Hygiene. In 1932 he became a full professor and de facto head of the Department, succeeding Dr. Fitzgerald in 1940.
A bacteriologist, he was "an enthusiastic proponent of the use of vaccines and antitoxins." In the early 1920s he "assisted in the research to improve the production of insulin", "was a member of the team that perfected diphtheria toxoid," and was also keenly interested in tetanus, scarlet fever, and whooping cough. Dr. Fraser introduced the science of microbiology into the curriculum, and was a widely respected teacher, fluent in French and German. He died in 1954.